6xdf: Difference between revisions
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==Crystal structure of IRE1a in complex with G-4100== | ==Crystal structure of IRE1a in complex with G-4100== | ||
<StructureSection load='6xdf' size='340' side='right'caption='[[6xdf]]' scene=''> | <StructureSection load='6xdf' size='340' side='right'caption='[[6xdf]], [[Resolution|resolution]] 2.54Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XDF FirstGlance]. <br> | <table><tr><td colspan='2'>[[6xdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XDF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xdf OCA], [https://pdbe.org/6xdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xdf RCSB], [https://www.ebi.ac.uk/pdbsum/6xdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xdf ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N94:4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide'>N94</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xdf OCA], [https://pdbe.org/6xdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xdf RCSB], [https://www.ebi.ac.uk/pdbsum/6xdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xdf ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0] | |||
==See Also== | |||
*[[Ire1|Ire1]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Steinbacher S]] | [[Category: Steinbacher S]] | ||
[[Category: Wang W]] | [[Category: Wang W]] |