6wz9: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 6wz9 is ON HOLD Authors: Description: Category: Unreleased Structures |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin== | |||
<StructureSection load='6wz9' size='340' side='right'caption='[[6wz9]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6wz9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WZ9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wz9 OCA], [https://pdbe.org/6wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wz9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Bilokapic S]] | |||
[[Category: Halic M]] | |||
Latest revision as of 17:47, 6 March 2024
Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatinBridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin
Structural highlights
FunctionH4_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. See Also |
| ||||||||||||||||