6vws: Difference between revisions
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New page: '''Unreleased structure''' The entry 6vws is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Hexamer of Helical HIV capsid by RASTR method== | |||
<StructureSection load='6vws' size='340' side='right'caption='[[6vws]], [[Resolution|resolution]] 6.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6vws]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VWS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.08Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vws OCA], [https://pdbe.org/6vws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vws RCSB], [https://www.ebi.ac.uk/pdbsum/6vws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vws ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | |||
==See Also== | |||
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]] | |||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Human immunodeficiency virus 1]] | |||
[[Category: Large Structures]] | |||
[[Category: Asturias F]] | |||
[[Category: Iqbal N]] | |||
[[Category: Kvaratskhelia M]] | |||
[[Category: Vanblerkom P]] | |||
[[Category: Zhao H]] | |||
Latest revision as of 17:40, 6 March 2024
Hexamer of Helical HIV capsid by RASTR methodHexamer of Helical HIV capsid by RASTR method
Structural highlights
FunctionGAG_HV1N5 Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). See Also |
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