5tss: Difference between revisions

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New page: left|200px<br /><applet load="5tss" size="450" color="white" frame="true" align="right" spinBox="true" caption="5tss, resolution 2.9Å" /> '''TOXIC SHOCK SYNDROME ...
 
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[[Image:5tss.gif|left|200px]]<br /><applet load="5tss" size="450" color="white" frame="true" align="right" spinBox="true"
caption="5tss, resolution 2.9&Aring;" />
'''TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM'''<br />


==Overview==
==TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM==
The structure of toxic shock syndrome toxin-1 (TSST-1), the causative, agent in toxic shock syndrome, has been determined in three crystal forms., The three structural models have been refined to R-factors of 0.154, 0.150, and 0.198 at resolutions of 2.05 A, 2.90 A, and 2.75 A, respectively. One crystal form of TSST-1 contains a zinc ion bound between, two symmetry-related molecules. Although not required for biological, activity, zinc dramatically potentiates the mitogenicity of TSST-1 at very, low concentrations. In addition, the structure of the tetramutant TSST-1H, [T69I, Y80W, E132K, I140T], which is nonmitogenic and does not amplify, endotoxin shock, has been determined and refined in a fourth crystal form, (R-factor = 0.173 to 1.9 A resolution).
<StructureSection load='5tss' size='340' side='right'caption='[[5tss]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[5tss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TSS FirstGlance]. <br>
5TSS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=5TSS OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tss OCA], [https://pdbe.org/5tss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tss RCSB], [https://www.ebi.ac.uk/pdbsum/5tss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tss ProSAT]</span></td></tr>
==Reference==
</table>
Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity., Prasad GS, Radhakrishnan R, Mitchell DT, Earhart CA, Dinges MM, Cook WJ, Schlievert PM, Ohlendorf DH, Protein Sci. 1997 Jun;6(6):1220-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9194182 9194182]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/5tss_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5tss ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Cook, W.J.]]
[[Category: Cook WJ]]
[[Category: Dinges, M.M.]]
[[Category: Dinges MM]]
[[Category: Earhart, C.A.]]
[[Category: Earhart CA]]
[[Category: Mitchell, D.T.]]
[[Category: Mitchell DT]]
[[Category: Ohlendorf, D.H.]]
[[Category: Ohlendorf DH]]
[[Category: Prasad, G.S.]]
[[Category: Prasad GS]]
[[Category: Radhakrishnan, R.]]
[[Category: Radhakrishnan R]]
[[Category: Schlivert, P.M.]]
[[Category: Schlivert PM]]
[[Category: signal]]
[[Category: superantigen]]
[[Category: toxin]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:28:18 2007''

Latest revision as of 17:23, 6 March 2024

TOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORMTOXIC SHOCK SYNDROME TOXIN-1: ORTHORHOMBIC P222(1) CRYSTAL FORM

Structural highlights

5tss is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TSST_STAAU Responsible for the symptoms of toxic shock syndrome.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

5tss, resolution 2.90Å

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