5tnc: Difference between revisions

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[[Image:5tnc.png|left|200px]]


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==REFINED CRYSTAL STRUCTURE OF TROPONIN C FROM TURKEY SKELETAL MUSCLE AT 2.0 ANGSTROMS RESOLUTION==
The line below this paragraph, containing "STRUCTURE_5tnc", creates the "Structure Box" on the page.
<StructureSection load='5tnc' size='340' side='right'caption='[[5tnc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[5tnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2tnc 2tnc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TNC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_5tnc|  PDB=5tnc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tnc OCA], [https://pdbe.org/5tnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tnc RCSB], [https://www.ebi.ac.uk/pdbsum/5tnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tnc ProSAT]</span></td></tr>
 
</table>
===REFINED CRYSTAL STRUCTURE OF TROPONIN C FROM TURKEY SKELETAL MUSCLE AT 2.0 ANGSTROMS RESOLUTION===
== Function ==
 
[https://www.uniprot.org/uniprot/TNNC2_MELGA TNNC2_MELGA] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
[[5tnc]] is a 1 chain structure of [[Troponin]] with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2tnc 2tnc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TNC OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5tnc ConSurf].
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==See Also==
==See Also==
*[[Troponin]]
*[[Troponin 3D structures|Troponin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:3210231</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Meleagris gallopavo]]
[[Category: Meleagris gallopavo]]
[[Category: Herzberg, O.]]
[[Category: Herzberg O]]
[[Category: James, M N.G.]]
[[Category: James MNG]]
[[Category: Contractile system protein]]

Latest revision as of 17:22, 6 March 2024

REFINED CRYSTAL STRUCTURE OF TROPONIN C FROM TURKEY SKELETAL MUSCLE AT 2.0 ANGSTROMS RESOLUTIONREFINED CRYSTAL STRUCTURE OF TROPONIN C FROM TURKEY SKELETAL MUSCLE AT 2.0 ANGSTROMS RESOLUTION

Structural highlights

5tnc is a 1 chain structure with sequence from Meleagris gallopavo. This structure supersedes the now removed PDB entry 2tnc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TNNC2_MELGA Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

5tnc, resolution 2.00Å

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