5tm2: Difference between revisions

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-'''Unreleased structure'''
-The entry 5tm2 is ON HOLD
+==Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 2,5-bis(2-chloro-4-hydroxyphenyl)thiophene 1-oxide==
+<StructureSection load='5tm2' size='340' side='right'caption='[[5tm2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5tm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TM2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.603&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7EO:2,5-BIS(2-CHLORO-4-HYDROXYPHENYL)-1H-1LAMBDA~4~-THIOPHEN-1-ONE'>7EO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tm2 OCA], [https://pdbe.org/5tm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tm2 RCSB], [https://www.ebi.ac.uk/pdbsum/5tm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tm2 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
+== Function ==
+[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
-Authors: Nwachukwu, J.C., Srinivasan, S., Bruno, N.E., Nowak, J., Kojetin, D.J., Elemento, O., Katzenellenbogen, J.A., Nettles, K.W.
+==See Also==
+*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
-Description: Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 2,5-bis(2-chloro-4-hydroxyphenyl)thiophene 1-oxide
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Nwachukwu, J.C]]
+__TOC__
-[[Category: Katzenellenbogen, J.A]]
+</StructureSection>
-[[Category: Bruno, N.E]]
+[[Category: Homo sapiens]]
-[[Category: Srinivasan, S]]
+[[Category: Large Structures]]
-[[Category: Kojetin, D.J]]
+[[Category: Bruno NE]]
-[[Category: Nowak, J]]
+[[Category: Elemento O]]
-[[Category: Nettles, K.W]]
+[[Category: Katzenellenbogen JA]]
-[[Category: Elemento, O]]
+[[Category: Kojetin DJ]]
+[[Category: Nettles KW]]
+[[Category: Nowak J]]
+[[Category: Nwachukwu JC]]
+[[Category: Srinivasan S]]