5s8c: Difference between revisions

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New page: '''Unreleased structure''' The entry 5s8c is ON HOLD Authors: Krojer, T., Talon, R., Fairhead, M., Szykowska, A., Burgess-Brown, N.A., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bo...
 
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'''Unreleased structure'''


The entry 5s8c is ON HOLD
==XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)==
<StructureSection load='5s8c' size='340' side='right'caption='[[5s8c]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5s8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S8C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RYD:(1-methylbenzotriazol-5-yl)methanol'>RYD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s8c OCA], [https://pdbe.org/5s8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s8c RCSB], [https://www.ebi.ac.uk/pdbsum/5s8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s8c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref>


Authors: Krojer, T., Talon, R., Fairhead, M., Szykowska, A., Burgess-Brown, N.A., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F.
==See Also==
 
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
Description: XChem group deposition --Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Edwards, A.M]]
__TOC__
[[Category: Arrowsmith, C.H]]
</StructureSection>
[[Category: Talon, R]]
[[Category: Homo sapiens]]
[[Category: Brennan, P.E]]
[[Category: Large Structures]]
[[Category: Szykowska, A]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N.A]]
[[Category: Bountra C]]
[[Category: Krojer, T]]
[[Category: Brennan PE]]
[[Category: Fairhead, M]]
[[Category: Burgess-Brown NA]]
[[Category: Von Delft, F]]
[[Category: Edwards AM]]
[[Category: Bountra, C]]
[[Category: Fairhead M]]
[[Category: Krojer T]]
[[Category: Szykowska A]]
[[Category: Talon R]]
[[Category: Von Delft F]]

Latest revision as of 17:16, 6 March 2024

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)

Structural highlights

5s8c is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.25Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PHIP_HUMAN Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2]

See Also

References

  1. ↑ Farhang-Fallah J, Randhawa VK, Nimnual A, Klip A, Bar-Sagi D, Rozakis-Adcock M. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol. 2002 Oct;22(20):7325-36. PMID:12242307
  2. ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54

5s8c, resolution 1.25Å

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