5pxm: Difference between revisions
New page: '''Unreleased structure''' The entry 5pxm is ON HOLD Authors: Krojer, T. Description: PanDDA analysis group deposition --Crystal Structure of SP100 after initial refinement with no lig... |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 46)== | |||
<StructureSection load='5pxm' size='340' side='right'caption='[[5pxm]], [[Resolution|resolution]] 1.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5pxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PXM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Krojer | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pxm OCA], [https://pdbe.org/5pxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pxm RCSB], [https://www.ebi.ac.uk/pdbsum/5pxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pxm ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Bradley AR]] | |||
[[Category: Brandao-Neto J]] | |||
[[Category: Brennan PE]] | |||
[[Category: Collins P]] | |||
[[Category: Cox O]] | |||
[[Category: Dias A]] | |||
[[Category: Douangamath A]] | |||
[[Category: Edwards A]] | |||
[[Category: Fairhead M]] | |||
[[Category: Krojer T]] | |||
[[Category: MacLean E]] | |||
[[Category: Ng J]] | |||
[[Category: Pearce NM]] | |||
[[Category: Renjie Z]] | |||
[[Category: Sethi R]] | |||
[[Category: Talon R]] | |||
[[Category: Wright N]] | |||
[[Category: Von Delft F]] | |||