5prx: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5prx is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 104)==
<StructureSection load='5prx' size='340' side='right'caption='[[5prx]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5prx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PRX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5prx OCA], [https://pdbe.org/5prx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5prx RCSB], [https://www.ebi.ac.uk/pdbsum/5prx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5prx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>


Authors: Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: PanDDA analysis group deposition --Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 104)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Pearce, N.M]]
__TOC__
[[Category: Collins, P]]
</StructureSection>
[[Category: Cox, O]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.H]]
[[Category: Large Structures]]
[[Category: Brandao-Neto, J]]
[[Category: Arrowsmith CH]]
[[Category: Fairhead, M]]
[[Category: Bountra C]]
[[Category: Von Delft, F]]
[[Category: Bradley AR]]
[[Category: Renjie, Z]]
[[Category: Brandao-Neto J]]
[[Category: Wright, N]]
[[Category: Brennan PE]]
[[Category: Ng, J]]
[[Category: Collins P]]
[[Category: Bradley, A.R]]
[[Category: Cox O]]
[[Category: Talon, R]]
[[Category: Dias A]]
[[Category: Brennan, P.E]]
[[Category: Douangamath A]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Douangamath, A]]
[[Category: Fairhead M]]
[[Category: Maclean, E]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: MacLean E]]
[[Category: Dias, A]]
[[Category: Ng J]]
[[Category: Sethi, R]]
[[Category: Pearce NM]]
[[Category: Bountra, C]]
[[Category: Renjie Z]]
[[Category: Sethi R]]
[[Category: Talon R]]
[[Category: Wright N]]
[[Category: Von Delft F]]

Latest revision as of 16:14, 6 March 2024

PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 104)PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 104)

Structural highlights

5prx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.87Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRD1_HUMAN Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5prx, resolution 1.87Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5prx&oldid=4081719"