5pp9: Difference between revisions

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'''Unreleased structure'''


The entry 5pp9 is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 9)==
<StructureSection load='5pp9' size='340' side='right'caption='[[5pp9]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5pp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PP9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pp9 OCA], [https://pdbe.org/5pp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pp9 RCSB], [https://www.ebi.ac.uk/pdbsum/5pp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pp9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRD1_HUMAN BRD1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:16387653</ref> <ref>PMID:21880731</ref>


Authors: Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: PanDDA analysis group deposition --Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 9)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Pearce, N.M]]
__TOC__
[[Category: Collins, P]]
</StructureSection>
[[Category: Cox, O]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.H]]
[[Category: Large Structures]]
[[Category: Brandao-Neto, J]]
[[Category: Arrowsmith CH]]
[[Category: Fairhead, M]]
[[Category: Bountra C]]
[[Category: Von Delft, F]]
[[Category: Bradley AR]]
[[Category: Renjie, Z]]
[[Category: Brandao-Neto J]]
[[Category: Wright, N]]
[[Category: Brennan PE]]
[[Category: Ng, J]]
[[Category: Collins P]]
[[Category: Bradley, A.R]]
[[Category: Cox O]]
[[Category: Talon, R]]
[[Category: Dias A]]
[[Category: Brennan, P.E]]
[[Category: Douangamath A]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Douangamath, A]]
[[Category: Fairhead M]]
[[Category: Maclean, E]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: MacLean E]]
[[Category: Dias, A]]
[[Category: Ng J]]
[[Category: Sethi, R]]
[[Category: Pearce NM]]
[[Category: Bountra, C]]
[[Category: Renjie Z]]
[[Category: Sethi R]]
[[Category: Talon R]]
[[Category: Wright N]]
[[Category: Von Delft F]]

Latest revision as of 16:10, 6 March 2024

PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 9)PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 9)

Structural highlights

5pp9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.82Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRD1_HUMAN Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem. 2011 Oct 21;286(42):36944-55. doi: 10.1074/jbc.M111.244400. Epub, 2011 Aug 31. PMID:21880731 doi:http://dx.doi.org/10.1074/jbc.M111.244400

5pp9, resolution 1.82Å

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