5phh: Difference between revisions
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New page: '''Unreleased structure''' The entry 5phh is ON HOLD Authors: Krojer, T. Description: PanDDA analysis group deposition --Crystal Structure of JMJD2D in complex with N09457a [[Category:... |
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==PanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09457a== | |||
<StructureSection load='5phh' size='340' side='right'caption='[[5phh]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5phh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PHH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.604Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LDP:L-DOPAMINE'>LDP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5phh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5phh OCA], [https://pdbe.org/5phh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5phh RCSB], [https://www.ebi.ac.uk/pdbsum/5phh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5phh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | |||
==See Also== | |||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Krojer | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Bradley AR]] | |||
[[Category: Brandao-Neto J]] | |||
[[Category: Brennan PE]] | |||
[[Category: Burgess-Brown N]] | |||
[[Category: Collins P]] | |||
[[Category: Cox O]] | |||
[[Category: Dias A]] | |||
[[Category: Douangamath A]] | |||
[[Category: Edwards A]] | |||
[[Category: Fairhead M]] | |||
[[Category: Krojer T]] | |||
[[Category: MacLean E]] | |||
[[Category: Ng J]] | |||
[[Category: Oppermann U]] | |||
[[Category: Pearce NM]] | |||
[[Category: Renjie Z]] | |||
[[Category: Sethi R]] | |||
[[Category: Szykowska A]] | |||
[[Category: Talon R]] | |||
[[Category: Vollmar M]] | |||
[[Category: Wright N]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 15:54, 6 March 2024
PanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09457aPanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09457a
Structural highlights
FunctionKDM4D_HUMAN Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.[1] See AlsoReferences
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