5kcf: Difference between revisions

<StructureSection load='5kcf' size='340' side='right'caption='[[5kcf]], [[Resolution|resolution]] 2.07&Aring;' scene=''>

<table><tr><td colspan='2'>[[5kcf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zwk 4zwk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KCF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OB4:(1S,2R,4S)-N-ETHYL-5,6-BIS(4-HYDROXYPHENYL)-N-(4-METHOXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2-SULFONAMIDE'>OB4</scene>, <scene name='pdbligand=OB5:(1R,2S,4R)-N-ETHYL-5,6-BIS(4-HYDROXYPHENYL)-N-(4-METHOXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2-SULFONAMIDE'>OB5</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kcf OCA], [https://pdbe.org/5kcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kcf RCSB], [https://www.ebi.ac.uk/pdbsum/5kcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kcf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ESR1_HUMAN ESR1_HUMAN] Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Isoform 3 can bind to ERE and inhibit isoform 1.<ref>PMID:7651415</ref> <ref>PMID:10970861</ref> <ref>PMID:9328340</ref> <ref>PMID:10681512</ref> <ref>PMID:10816575</ref> <ref>PMID:11477071</ref> <ref>PMID:11682626</ref> <ref>PMID:15078875</ref> <ref>PMID:16043358</ref> <ref>PMID:15891768</ref> <ref>PMID:16684779</ref> <ref>PMID:18247370</ref> <ref>PMID:17932106</ref> <ref>PMID:19350539</ref> <ref>PMID:20705611</ref> <ref>PMID:21937726</ref> <ref>PMID:21330404</ref> <ref>PMID:22083956</ref>  

 

[[Category: Boonmuen N]]

[[Category: Bruno NE]]

[[Category: Dharmarajan V]]

[[Category: Frasor J]]

[[Category: Goswami D]]

[[Category: Griffin PR]]

[[Category: Kastrati I]]

[[Category: Katzenellenbogen BS]]

[[Category: Katzenellenbogen JA]]

[[Category: Min J]]

[[Category: Nettles KW]]

[[Category: Novick S]]

[[Category: Nowak J]]

[[Category: Nwachukwu JC]]

[[Category: Srinivasan S]]

[[Category: Zhao Y]]

[[Category: Zhou HB]]