5erc: Difference between revisions

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New page: '''Unreleased structure''' The entry 5erc is ON HOLD Authors: Klein, B.J., Andrews, F.H., Kutateladze, T.G. Description: X-ray crystal structure of BRPF1 PZP domain [[Category: Unrelea...
 
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'''Unreleased structure'''


The entry 5erc is ON HOLD
==X-ray crystal structure of BRPF1 PZP domain==
<StructureSection load='5erc' size='340' side='right'caption='[[5erc]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5erc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ERC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5erc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5erc OCA], [https://pdbe.org/5erc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5erc RCSB], [https://www.ebi.ac.uk/pdbsum/5erc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5erc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>


Authors: Klein, B.J., Andrews, F.H., Kutateladze, T.G.
==See Also==
 
*[[Peregrin|Peregrin]]
Description: X-ray crystal structure of BRPF1 PZP domain
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Klein, B.J]]
__TOC__
[[Category: Kutateladze, T.G]]
</StructureSection>
[[Category: Andrews, F.H]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Andrews FH]]
[[Category: Klein BJ]]
[[Category: Kutateladze TG]]

Latest revision as of 15:29, 6 March 2024

X-ray crystal structure of BRPF1 PZP domainX-ray crystal structure of BRPF1 PZP domain

Structural highlights

5erc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRPF1_HUMAN Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.[1] [2]

See Also

References

  1. ↑ Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS, Tan S, Yang XJ, Cote J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6;21(1):51-64. PMID:16387653 doi:10.1016/j.molcel.2005.12.007
  2. ↑ Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Cote J, Yang XJ. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep , 15. PMID:18794358 doi:10.1128/MCB.01297-08

5erc, resolution 2.05Å

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