5eqe: Difference between revisions

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'''Unreleased structure'''


The entry 5eqe is ON HOLD  until Paper Publication
==Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)==
<StructureSection load='5eqe' size='340' side='right'caption='[[5eqe]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5eqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5R8:[4-[(4-METHYL-1,4-DIAZEPAN-1-YL)METHYL]PHENYL]METHANAMINE'>5R8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqe OCA], [https://pdbe.org/5eqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqe RCSB], [https://www.ebi.ac.uk/pdbsum/5eqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqe ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>


Authors: Zhou, T., Zhu, X., Dalgarno, D.C.
==See Also==
 
*[[Choline kinase 3D structures|Choline kinase 3D structures]]
Description: Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 3)
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Dalgarno, D.C]]
__TOC__
[[Category: Zhou, T]]
</StructureSection>
[[Category: Zhu, X]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dalgarno DC]]
[[Category: Zhou T]]
[[Category: Zhu X]]

Latest revision as of 15:29, 6 March 2024

Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)

Structural highlights

5eqe is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CHKA_HUMAN Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.[1]

See Also

References

  1. ↑ Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS One. 2009 Nov 12;4(11):e7819. doi: 10.1371/journal.pone.0007819. PMID:19915674 doi:10.1371/journal.pone.0007819

5eqe, resolution 2.40Å

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