5dqq: Difference between revisions

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'''Unreleased structure'''


The entry 5dqq is ON HOLD
==Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana==
<StructureSection load='5dqq' size='340' side='right'caption='[[5dqq]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5dqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DQQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.872&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=66R:TRANS-NED+19'>66R</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dqq OCA], [https://pdbe.org/5dqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dqq RCSB], [https://www.ebi.ac.uk/pdbsum/5dqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dqq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPC1_ARATH TPC1_ARATH] Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.<ref>PMID:15464979</ref> <ref>PMID:15772667</ref>


Authors: Kintzer, A.F., Stroud, R.M.
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Kintzer, A.F]]
__TOC__
[[Category: Stroud, R.M]]
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Kintzer AF]]
[[Category: Stroud RM]]

Latest revision as of 15:25, 6 March 2024

Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thalianaStructure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana

Structural highlights

5dqq is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.872Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPC1_ARATH Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the vacuole membrane. Is one of the essential components of the slow vacuolar (SV) channel. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Involved in the regulation of germination and stomatal movement.[1] [2]

See Also

References

  1. ↑ Kawano T, Kadono T, Fumoto K, Lapeyrie F, Kuse M, Isobe M, Furuichi T, Muto S. Aluminum as a specific inhibitor of plant TPC1 Ca2+ channels. Biochem Biophys Res Commun. 2004 Nov 5;324(1):40-5. PMID:15464979 doi:http://dx.doi.org/S0006-291X(04)02051-0
  2. ↑ Peiter E, Maathuis FJ, Mills LN, Knight H, Pelloux J, Hetherington AM, Sanders D. The vacuolar Ca2+-activated channel TPC1 regulates germination and stomatal movement. Nature. 2005 Mar 17;434(7031):404-8. PMID:15772667 doi:http://dx.doi.org/nature03381

5dqq, resolution 2.87Å

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