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New page: '''Unreleased structure''' The entry 5dob is ON HOLD Authors: Lye, M.F., El Omari, K., Filman, D.J., Hogle, J.M. Description: Category: Unreleased Structures [[Category: Hogle, J.... |
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==Crystal structure of the Human Cytomegalovirus Nuclear Egress Complex (NEC)== | |||
<StructureSection load='5dob' size='340' side='right'caption='[[5dob]], [[Resolution|resolution]] 2.47Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5dob]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DOB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dob OCA], [https://pdbe.org/5dob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dob RCSB], [https://www.ebi.ac.uk/pdbsum/5dob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dob ProSAT]</span></td></tr> | ||
[[Category: Filman | </table> | ||
[[Category: | == Function == | ||
[[Category: Lye | [https://www.uniprot.org/uniprot/NEC1_HCMVA NEC1_HCMVA] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04023]<ref>PMID:25339763</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human herpesvirus 5 strain AD169]] | |||
[[Category: Large Structures]] | |||
[[Category: El Omari K]] | |||
[[Category: Filman DJ]] | |||
[[Category: Hogle JM]] | |||
[[Category: Lye MF]] | |||
Latest revision as of 15:25, 6 March 2024
Crystal structure of the Human Cytomegalovirus Nuclear Egress Complex (NEC)Crystal structure of the Human Cytomegalovirus Nuclear Egress Complex (NEC)
Structural highlights
FunctionNEC1_HCMVA Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04023][1] References
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