5d6x: Difference between revisions

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-'''Unreleased structure'''
-The entry 5d6x is ON HOLD
+==Crystal structure of double tudor domain of human lysine demethylase KDM4A==
+<StructureSection load='5d6x' size='340' side='right'caption='[[5d6x]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5d6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D6X FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.153&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d6x OCA], [https://pdbe.org/5d6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d6x RCSB], [https://www.ebi.ac.uk/pdbsum/5d6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d6x ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>   Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
-Authors: Wang, F., Su, Z., Denu, J.M., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
+==See Also==
+*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-Description: Crystal structure of double tudor domain of human lysine demethylase KDM4A
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: G.N]]
+__TOC__
-[[Category: Su, Z]]
+</StructureSection>
-[[Category: Denu, J.M]]
+[[Category: Homo sapiens]]
-[[Category: Enzyme Discovery For Natural Product Biosynthesis (Natpro)]]
+[[Category: Large Structures]]
-[[Category: Wang, F]]
+[[Category: Denu JM]]
-[[Category: Phillips Jr]]
+[[Category: Phillips Jr GN]]
+[[Category: Su Z]]
+[[Category: Wang F]]