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==Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex== | |||
<StructureSection load='5cww' size='340' side='right'caption='[[5cww]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cww]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CWW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cww OCA], [https://pdbe.org/5cww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cww RCSB], [https://www.ebi.ac.uk/pdbsum/5cww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cww ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NU145_CHATD NU145_CHATD] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export.[UniProtKB:P49687] | |||
==See Also== | |||
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Chaetomium thermophilum var. thermophilum DSM 1495]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bley CJ]] | ||
[[Category: | [[Category: Collins LN]] | ||
[[Category: | [[Category: Fischer J]] | ||
[[Category: | [[Category: Hoelz A]] | ||
[[Category: | [[Category: Hurt E]] | ||
[[Category: | [[Category: Jeon YE]] | ||
[[Category: | [[Category: Koide A]] | ||
[[Category: | [[Category: Koide S]] | ||
[[Category: | [[Category: Kossiakoff AA]] | ||
[[Category: | [[Category: Lin DH]] | ||
[[Category: | [[Category: Lu V]] | ||
[[Category: | [[Category: Mayo DJ]] | ||
[[Category: | [[Category: Paduch M]] | ||
[[Category: | [[Category: Perriches T]] | ||
[[Category: | [[Category: Petrovic S]] | ||
[[Category: Stuwe | [[Category: Rundlet EJ]] | ||
[[Category: | [[Category: Schilbach S]] | ||
[[Category: Stuwe T]] | |||
[[Category: Thierbach K]] | |||
Latest revision as of 15:22, 6 March 2024
Crystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complexCrystal structure of the Chaetomium thermophilum heterotrimeric Nup82 NTD-Nup159 TAIL-Nup145N APD complex
Structural highlights
FunctionNU145_CHATD Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. NUP145 is autocatalytically cleaved in vivo in 2 polypeptides which assume different functions in the NPC. NUP145N as one of the FG repeat nucleoporins participates in karyopherin interactions and contains part of the autocatalytic cleavage activity. NUP145C as part of the NUP84 complex is involved in nuclear poly(A)+ RNA and tRNA export.[UniProtKB:P49687] See Also |
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