5cqb: Difference between revisions

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'''Unreleased structure'''


The entry 5cqb is ON HOLD  until Paper Publication
==Crystal structure of E. coli undecaprenyl pyrophosphate synthase==
<StructureSection load='5cqb' size='340' side='right'caption='[[5cqb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CQB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqb OCA], [https://pdbe.org/5cqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cqb RCSB], [https://www.ebi.ac.uk/pdbsum/5cqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cqb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>


Authors: Worrall, L.J., Conrady, D.G., Strynadka, N.C.
==See Also==
 
*[[Undecaprenyl pyrophosphate synthase|Undecaprenyl pyrophosphate synthase]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Conrady, D.G]]
__TOC__
[[Category: Worrall, L.J]]
</StructureSection>
[[Category: Strynadka, N.C]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Conrady DG]]
[[Category: Strynadka NC]]
[[Category: Worrall LJ]]

Latest revision as of 15:21, 6 March 2024

Crystal structure of E. coli undecaprenyl pyrophosphate synthaseCrystal structure of E. coli undecaprenyl pyrophosphate synthase

Structural highlights

5cqb is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UPPS_ECOLI Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.[1]

See Also

References

  1. ↑ Chang SY, Ko TP, Liang PH, Wang AH. Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton. J Biol Chem. 2003 Aug 1;278(31):29298-307. Epub 2003 May 19. PMID:12756244 doi:10.1074/jbc.M302687200

5cqb, resolution 2.20Å

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