2idv: Difference between revisions

No edit summary
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2idv.png|left|200px]]


{{STRUCTURE_2idv|  PDB=2idv  |  SCENE=  }}
==Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP==
 
<StructureSection load='2idv' size='340' side='right'caption='[[2idv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of wheat C113S mutant EIF4E bound TO 7-methyl-GDP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2idv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IDV FirstGlance]. <br>
{{ABSTRACT_PUBMED_17322339}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2idv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2idv OCA], [https://pdbe.org/2idv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2idv RCSB], [https://www.ebi.ac.uk/pdbsum/2idv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2idv ProSAT]</span></td></tr>
[[2idv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDV OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4E1_WHEAT IF4E1_WHEAT] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/2idv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2idv ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:017322339</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Triticum aestivum]]
[[Category: Triticum aestivum]]
[[Category: Browning, K S.]]
[[Category: Browning KS]]
[[Category: Dhaliwal, S.]]
[[Category: Dhaliwal S]]
[[Category: Dutt-Chaudhuri, A.]]
[[Category: Dutt-Chaudhuri A]]
[[Category: Hoffman, D W.]]
[[Category: Hoffman DW]]
[[Category: Monzingo, A F.]]
[[Category: Monzingo AF]]
[[Category: Robertus, J D.]]
[[Category: Robertus JD]]
[[Category: Sadow, J.]]
[[Category: Sadow J]]
[[Category: Cap]]
[[Category: Eif4e]]
[[Category: Eukaryotic initiation factor 4e]]
[[Category: Methyl-7-gdp]]
[[Category: Translation regulator]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA