Nuclear receptors: Difference between revisions
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F: C-terminal domain | F: C-terminal domain | ||
See also [[Receptor]] | See also: | ||
*[[Receptor]] | |||
*[[Steroid Hormones and their receptors]] | |||
*[[Intracellular receptors]] | |||
=Thyroid Hormone Receptor-like= | =Thyroid Hormone Receptor-like= | ||
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==Estrogen receptor== | ==Estrogen receptor== | ||
*[[Estrogen receptor]] | *[[Estrogen receptor]] | ||
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | <scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with [[raloxifene]] and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]). | ||
Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs<ref>PMID: 21473635</ref>. | Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of SERMs<ref>PMID: 21473635</ref>. | ||
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Upon visualizing the estrogen receptor in an <scene name='48/483891/Arrow_view/1'>arrow representation</scene>, the structure can be classified as parallel or anti-parallel. Here is the zoomed <scene name='48/483891/Hydrophobic_pocket/3'>primarily hydrophobic pocket</scene>. | Upon visualizing the estrogen receptor in an <scene name='48/483891/Arrow_view/1'>arrow representation</scene>, the structure can be classified as parallel or anti-parallel. Here is the zoomed <scene name='48/483891/Hydrophobic_pocket/3'>primarily hydrophobic pocket</scene>. | ||
== [[Estrogen-related receptor]]== | == [[Estrogen-related receptor]]== | ||
**[[Tamoxifen|Tamoxifen and the Estrogen Receptor/Tamoxifen and the Estrogen-related receptor]] | |||
<scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site. | <scene name='50/501401/Cv/4'>Binding of nuclear receptor corepressor 2 peptide and 4-hydroxytamoxifen</scene> to human estrogen-related receptor γ. The chemotherapeutic drugs bisphenol and <scene name='50/501401/Cv/5'>tamoxifen</scene> are nestled between 4 alpha helices in the ERR active site. | ||
== 3-Ketosteroid receptors== | == 3-Ketosteroid receptors== | ||