5rjl: Difference between revisions

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==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024662==
==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024662==
<StructureSection load='5rjl' size='340' side='right'caption='[[5rjl]]' scene=''>
<StructureSection load='5rjl' size='340' side='right'caption='[[5rjl]], [[Resolution|resolution]] 1.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RJL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5RJL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5rjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RJL FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5rjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rjl OCA], [http://pdbe.org/5rjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5rjl RCSB], [http://www.ebi.ac.uk/pdbsum/5rjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5rjl ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.31&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UUG:(4-bromo-2-methoxyphenyl)methanol'>UUG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rjl OCA], [https://pdbe.org/5rjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rjl RCSB], [https://www.ebi.ac.uk/pdbsum/5rjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rjl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref>
==See Also==
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aimon A]]
[[Category: Aimon A]]

Latest revision as of 16:50, 1 March 2024

PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024662PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with NCL-00024662

Structural highlights

5rjl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.31Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PHIP_HUMAN Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.[1] [2]

See Also

References

  1. ↑ Farhang-Fallah J, Randhawa VK, Nimnual A, Klip A, Bar-Sagi D, Rozakis-Adcock M. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol. 2002 Oct;22(20):7325-36. PMID:12242307
  2. ↑ Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54. PMID:21834987 doi:10.1186/1741-7007-9-54

5rjl, resolution 1.31Å

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OCA
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