3q0h: Difference between revisions

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[[Image:3q0h.jpg|left|200px]]


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==Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)==
The line below this paragraph, containing "STRUCTURE_3q0h", creates the "Structure Box" on the page.
<StructureSection load='3q0h' size='340' side='right'caption='[[3q0h]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3q0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0h OCA], [https://pdbe.org/3q0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0h RCSB], [https://www.ebi.ac.uk/pdbsum/3q0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0h ProSAT]</span></td></tr>
{{STRUCTURE_3q0h|  PDB=3q0h  |  SCENE=  }}
</table>
 
== Function ==
===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)===
[https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
 
__TOC__
 
</StructureSection>
==About this Structure==
[[3q0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0H OCA].  
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Large Structures]]
[[Category: Guo, H.]]
[[Category: Almo SC]]
[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
[[Category: Guo H]]
[[Category: Nathenson, S G.]]
[[Category: Nathenson SG]]
[[Category: Ramagopal, U A.]]
[[Category: Ramagopal UA]]
[[Category: Samanta, D.]]
[[Category: Samanta D]]

Latest revision as of 16:36, 1 March 2024

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

Structural highlights

3q0h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TIGIT_HUMAN Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

3q0h, resolution 1.70Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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