3pz4: Difference between revisions

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-[[Image:3pz4.png|left|200px]]
-{{STRUCTURE_3pz4|  PDB=3pz4  |  SCENE=  }}
+==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==
+<StructureSection load='3pz4' size='340' side='right'caption='[[3pz4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[3pz4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
 ==See Also==
-*[[Farnesyltransferase|Farnesyltransferase]]
+*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:021520375</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Mus musculus]]
+[[Category: Rattus norvegicus]]
-[[Category: Protein farnesyltransferase]]
+[[Category: Alexandrov K]]
-[[Category: Alexandrov, K.]]
+[[Category: Blankenfeldt W]]
-[[Category: Blankenfeldt, W.]]
+[[Category: Bon RS]]
-[[Category: Bon, R S.]]
+[[Category: Goody RS]]
-[[Category: Goody, R S.]]
+[[Category: Guo Z]]
-[[Category: Guo, Z.]]
+[[Category: Stigter EA]]
-[[Category: Stigter, E A.]]
+[[Category: Waldmann H]]
-[[Category: Waldmann, H.]]
-[[Category: Protein prenylation]]
-[[Category: Transferase-transferase inhibitor complex]]