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{{STRUCTURE_3pz3|  PDB=3pz3  |  SCENE=  }}
===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14===


==Function==
==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14==
[[http://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [[http://www.uniprot.org/uniprot/PGTB2_RAT PGTB2_RAT]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.  
<StructureSection load='3pz3' size='340' side='right'caption='[[3pz3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3pz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PZ3:4-({(3R)-7-(5-FORMYLFURAN-2-YL)-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+BENZYLCARBAMATE'>PZ3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz3 OCA], [https://pdbe.org/3pz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.


==About this Structure==
==See Also==
[[3pz3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ3 OCA].
*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Rattus norvegicus]]
[[Category: Protein geranylgeranyltransferase type II]]
[[Category: Alexandrov K]]
[[Category: Alexandrov, K.]]
[[Category: Blankenfeldt W]]
[[Category: Blankenfeldt, W.]]
[[Category: Bon RS]]
[[Category: Bon, R S.]]
[[Category: Goody RS]]
[[Category: Goody, R S.]]
[[Category: Guo Z]]
[[Category: Guo, Z.]]
[[Category: Stigter EA]]
[[Category: Stigter, E A.]]
[[Category: Waldmann H]]
[[Category: Waldmann, H.]]
[[Category: Chimera protein]]
[[Category: Fusion protein]]
[[Category: Protein prenylation]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 16:35, 1 March 2024

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14

Structural highlights

3pz3 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PGTA_RAT Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

See Also

3pz3, resolution 2.00Å

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