3pz3: Difference between revisions
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==Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14== | |||
<StructureSection load='3pz3' size='340' side='right'caption='[[3pz3]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3pz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PZ3:4-({(3R)-7-(5-FORMYLFURAN-2-YL)-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-3-YL}METHYL)PHENYL+BENZYLCARBAMATE'>PZ3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz3 OCA], [https://pdbe.org/3pz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. | |||
==See Also== | |||
*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Alexandrov K]] | |||
[[Category: Blankenfeldt W]] | |||
[[Category: Bon RS]] | |||
[[Category: Goody RS]] | |||
[[Category: Guo Z]] | |||
[[Category: Stigter EA]] | |||
[[Category: Waldmann H]] | |||
Latest revision as of 16:35, 1 March 2024
Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS-analogue 14
Structural highlights
FunctionPGTA_RAT Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. See Also |
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