7ti8: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 7ti8 is ON HOLD
+==Structure of the yeast clamp loader (Replication Factor C RFC) bound to the open sliding clamp (Proliferating Cell Nuclear Antigen PCNA)==
+<StructureSection load='7ti8' size='340' side='right'caption='[[7ti8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ti8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TI8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ti8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ti8 OCA], [https://pdbe.org/7ti8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ti8 RCSB], [https://www.ebi.ac.uk/pdbsum/7ti8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ti8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RFC1_YEAST RFC1_YEAST] Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment.
-Authors: Gaubitz, C., Liu, X., Pajak, J., Stone, N., Hayes, J., Demo, G., Kelch, B.A.
+==See Also==
+*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
-Description: Structure of the yeast clamp loader (Replication Factor C RFC) bound to the open sliding clamp (Proliferating Cell Nuclear Antigen PCNA)
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Stone, N]]
+[[Category: Large Structures]]
-[[Category: Demo, G]]
+[[Category: Saccharomyces cerevisiae]]
-[[Category: Pajak, J]]
+[[Category: Demo G]]
-[[Category: Hayes, J]]
+[[Category: Gaubitz C]]
-[[Category: Liu, X]]
+[[Category: Hayes J]]
-[[Category: Gaubitz, C]]
+[[Category: Kelch BA]]
-[[Category: Kelch, B.A]]
+[[Category: Liu X]]
+[[Category: Pajak J]]
+[[Category: Stone N]]