7teo: Difference between revisions
No edit summary |
No edit summary |
||
(2 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
The | ==Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle in complex with FUB1== | ||
<StructureSection load='7teo' size='340' side='right'caption='[[7teo]], [[Resolution|resolution]] 2.97Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7teo]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TEO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.97Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7teo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7teo OCA], [https://pdbe.org/7teo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7teo RCSB], [https://www.ebi.ac.uk/pdbsum/7teo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7teo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Hanna J]] | |||
[[Category: Rawson S]] | |||
[[Category: Schnell HM]] | |||
[[Category: Walsh Jr RM]] |