4yl1: Difference between revisions

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New page: '''Unreleased structure''' The entry 4yl1 is ON HOLD until sometime in the future Authors: Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J. Description: Crystal Structures of mPG...
 
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'''Unreleased structure'''


The entry 4yl1 is ON HOLD  until sometime in the future
==Crystal Structures of mPGES-1 Inhibitor Complexes==
<StructureSection load='4yl1' size='340' side='right'caption='[[4yl1]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4yl1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YL1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4U8:5-(4-TERT-BUTYLPHENYL)-1-[4-(PROPAN-2-YLOXY)PHENYL]-1H-INDOLE-2-CARBOXYLIC+ACID'>4U8</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yl1 OCA], [https://pdbe.org/4yl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4yl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yl1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>


Authors: Luz, J.G., Antonysamy, S., Kuklish, S.L., Fisher, M.J.
==See Also==
 
*[[Prostaglandin E synthase|Prostaglandin E synthase]]
Description: Crystal Structures of mPGES-1 Inhibitor Complexes
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Luz, J.G]]
__TOC__
[[Category: Fisher, M.J]]
</StructureSection>
[[Category: Kuklish, S.L]]
[[Category: Homo sapiens]]
[[Category: Antonysamy, S]]
[[Category: Large Structures]]
[[Category: Antonysamy S]]
[[Category: Fisher MJ]]
[[Category: Kuklish SL]]
[[Category: Luz JG]]

Latest revision as of 16:03, 1 March 2024

Crystal Structures of mPGES-1 Inhibitor ComplexesCrystal Structures of mPGES-1 Inhibitor Complexes

Structural highlights

4yl1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.41Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTGES_HUMAN Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).[1]

See Also

References

  1. ↑ Jegerschold C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Hebert H. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11110-5. Epub 2008 Aug 5. PMID:18682561 doi:0802894105

4yl1, resolution 1.41Å

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