4v6i: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4v6i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izb 3izb], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ize 3ize], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izf 3izf], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izs 3izs] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izc 3izc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V6I FirstGlance]. <br>
<table><tr><td colspan='2'>[[4v6i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izb 3izb], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ize 3ize], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izf 3izf], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izs 3izs] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3izc 3izc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V6I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v6i OCA], [https://pdbe.org/4v6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v6i RCSB], [https://www.ebi.ac.uk/pdbsum/4v6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v6i ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v6i OCA], [https://pdbe.org/4v6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v6i RCSB], [https://www.ebi.ac.uk/pdbsum/4v6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/GBLP_YEAST GBLP_YEAST] Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins.<ref>PMID:15340087</ref>  
[https://www.uniprot.org/uniprot/GBLP_YEAST GBLP_YEAST] Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins.<ref>PMID:15340087</ref>  
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== Publication Abstract from PubMed ==
Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-A resolution. This map, together with a 6.1-A map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model approximately 98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.,Armache JP, Jarasch A, Anger AM, Villa E, Becker T, Bhushan S, Jossinet F, Habeck M, Dindar G, Franckenberg S, Marquez V, Mielke T, Thomm M, Berninghausen O, Beatrix B, Soding J, Westhof E, Wilson DN, Beckmann R Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19748-53. Epub 2010 Oct 27. PMID:20980660<ref>PMID:20980660</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4v6i" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA