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==Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9==
==Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9==
<StructureSection load='4rs9' size='340' side='right' caption='[[4rs9]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4rs9' size='340' side='right'caption='[[4rs9]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rs9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RS9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RS9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rqw|4rqw]], [[4rru|4rru]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rs9 RCSB], [http://www.ebi.ac.uk/pdbsum/4rs9 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rs9 OCA], [https://pdbe.org/4rs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rs9 RCSB], [https://www.ebi.ac.uk/pdbsum/4rs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rs9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MYC3_ARATH MYC3_ARATH]] Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters.<ref>PMID:12136026</ref> <ref>PMID:21242320</ref> <ref>PMID:21321051</ref> <ref>PMID:21335373</ref> <ref>PMID:23943862</ref>  [[http://www.uniprot.org/uniprot/TIF7_ARATH TIF7_ARATH]] Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY7/JAZ9 interaction.<ref>PMID:19151223</ref>
[https://www.uniprot.org/uniprot/TIF7_ARATH TIF7_ARATH] Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY7/JAZ9 interaction.<ref>PMID:19151223</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Brunzelle, J S]]
[[Category: Arabidopsis thaliana]]
[[Category: He, S Y]]
[[Category: Large Structures]]
[[Category: Ke, J]]
[[Category: Brunzelle JS]]
[[Category: Melcher, K]]
[[Category: He SY]]
[[Category: Xu, H E]]
[[Category: Ke J]]
[[Category: Zhang, F]]
[[Category: Melcher K]]
[[Category: Zhou, M]]
[[Category: Xu HE]]
[[Category: Zhou, X E]]
[[Category: Zhang F]]
[[Category: Alpha+beta structural fold]]
[[Category: Zhou M]]
[[Category: Bind jaz corepressors or mediator subunit med25]]
[[Category: Zhou XE]]
[[Category: Helix-sheet-helix]]
[[Category: Nuclear]]
[[Category: Transcription factor]]
[[Category: Transcription regulator]]

Latest revision as of 15:55, 1 March 2024

Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9Structure of Myc3 N-terminal JAZ-binding domain [44-238] in complex with Jas motif of JAZ9

Structural highlights

4rs9 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TIF7_ARATH Repressor of jasmonate responses negatively regulated by the proteasome in an SCF(COI1) E3 ubiquitin-protein ligase complex-dependent manner. Jasmonoyl-isoleucine (JA-Ile) specifically promotes COI1-TIFY7/JAZ9 interaction.[1]

References

  1. ↑ Chung HS, Howe GA. A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis. Plant Cell. 2009 Jan;21(1):131-45. doi: 10.1105/tpc.108.064097. Epub 2009 Jan 16. PMID:19151223 doi:http://dx.doi.org/10.1105/tpc.108.064097

4rs9, resolution 1.95Å

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