4pyq: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4pyq is ON HOLD  until Paper Publication
+==Humanized rat apo-COMT in complex with a ureido-benzamidine==
+<StructureSection load='4pyq' size='340' side='right'caption='[[4pyq]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pyq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PYQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X1:4-({[3-(AMINOMETHYL)PHENYL]CARBAMOYL}AMINO)BENZENECARBOXIMIDAMIDE'>2X1</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pyq OCA], [https://pdbe.org/4pyq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pyq RCSB], [https://www.ebi.ac.uk/pdbsum/4pyq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pyq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
-Authors: Ehler, A., Benz, J., Schlatter, D., Rudolph, M.G.
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
-Description: Humanized rat apo-COMT in complex with a ureido-benzamidine
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Benz J]]
+[[Category: Ehler A]]
+[[Category: Rudolph MG]]
+[[Category: Schlatter D]]