4pym: Difference between revisions
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==humanized rat apo-COMT bound to sulphate== | ==humanized rat apo-COMT bound to sulphate== | ||
<StructureSection load='4pym' size='340' side='right' caption='[[4pym]], [[Resolution|resolution]] 1.19Å' scene=''> | <StructureSection load='4pym' size='340' side='right'caption='[[4pym]], [[Resolution|resolution]] 1.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pym]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYM OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4pym]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PYM FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pym OCA], [https://pdbe.org/4pym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pym RCSB], [https://www.ebi.ac.uk/pdbsum/4pym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pym ProSAT]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | |||
==See Also== | |||
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Benz | [[Category: Rattus norvegicus]] | ||
[[Category: Ehler | [[Category: Benz J]] | ||
[[Category: Rudolph | [[Category: Ehler A]] | ||
[[Category: Schlatter | [[Category: Rudolph MG]] | ||
[[Category: Schlatter D]] | |||