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==Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide==
==Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide==
<StructureSection load='4pxq' size='340' side='right' caption='[[4pxq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4pxq' size='340' side='right'caption='[[4pxq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4pxq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PXQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4pxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PXQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pw2|4pw2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heparosan-N-sulfate-glucuronate_5-epimerase Heparosan-N-sulfate-glucuronate 5-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.17 5.1.3.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxq OCA], [https://pdbe.org/4pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pxq RCSB], [https://www.ebi.ac.uk/pdbsum/4pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pxq RCSB], [http://www.ebi.ac.uk/pdbsum/4pxq PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLCEB_DANRE GLCEB_DANRE] Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).<ref>PMID:16156897</ref> <ref>PMID:25568314</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Heparosan-N-sulfate-glucuronate 5-epimerase]]
[[Category: Danio rerio]]
[[Category: Brunzelle, J S]]
[[Category: Large Structures]]
[[Category: Ding, K]]
[[Category: Brunzelle JS]]
[[Category: Gu, X]]
[[Category: Ding K]]
[[Category: Ke, J]]
[[Category: Gu X]]
[[Category: Qin, Y]]
[[Category: Ke J]]
[[Category: Tan, J]]
[[Category: Qin Y]]
[[Category: Xu, H E]]
[[Category: Tan J]]
[[Category: Epimerization enzyme]]
[[Category: Xu HE]]
[[Category: Heparan sulfate]]
[[Category: Heparan sulfate c5-epimerase]]
[[Category: Heparin]]
[[Category: Isomerase]]
[[Category: Multiple domain structure]]

Latest revision as of 15:43, 1 March 2024

Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharideCrystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide

Structural highlights

4pxq is a 2 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLCEB_DANRE Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).[1] [2]

References

  1. ↑ Ghiselli G, Farber SA. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol. 2005 Sep 12;5:19. PMID:16156897 doi:10.1186/1471-213X-5-19
  2. ↑ Qin Y, Ke J, Gu X, Fang J, Wang W, Cong Q, Li J, Tan J, Brunzelle JS, Zhang C, Jiang Y, Melcher K, Li JP, Xu HE, Ding K. Structural and functional study of D-glucuronyl C5-epimerase. J Biol Chem. 2015 Jan 7. pii: jbc.M114.602201. PMID:25568314 doi:http://dx.doi.org/10.1074/jbc.M114.602201

4pxq, resolution 2.20Å

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