4pxq: Difference between revisions
New page: '''Unreleased structure''' The entry 4pxq is ON HOLD Authors: Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K. Description: Crystal structure of D-glucuronyl C5-ep... |
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==Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide== | |||
<StructureSection load='4pxq' size='340' side='right'caption='[[4pxq]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4pxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PXQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=UAP:4-DEOXY-2-O-SULFO-ALPHA-L-THREO-HEX-4-ENOPYRANURONIC+ACID'>UAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pxq OCA], [https://pdbe.org/4pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pxq RCSB], [https://www.ebi.ac.uk/pdbsum/4pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pxq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLCEB_DANRE GLCEB_DANRE] Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).<ref>PMID:16156897</ref> <ref>PMID:25568314</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Danio rerio]] | |||
[[Category: Large Structures]] | |||
[[Category: Brunzelle JS]] | |||
[[Category: Ding K]] | |||
[[Category: Gu X]] | |||
[[Category: Ke J]] | |||
[[Category: Qin Y]] | |||
[[Category: Tan J]] | |||
[[Category: Xu HE]] | |||