4pnp: Difference between revisions

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-[[Image:4pnp.gif|left|200px]]
- {{Structure
+==THE HIGH RESOLUTION CRYSTAL STRUCTURE OF BOVINE SPLEEN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX FORMS WITH PHOSPHATE AND 9-DEAZAINOSINE==
-|PDB= 4pnp |SIZE=350|CAPTION= <scene name='initialview01'>4pnp</scene>, resolution 1.8&Aring;
+<StructureSection load='4pnp' size='340' side='right'caption='[[4pnp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-|SITE= <scene name='pdbsite=9DI:9-Deazainosine+Binding+Site'>9DI</scene> and <scene name='pdbsite=PO4:Phosphate+Binding+Site'>PO4</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+<table><tr><td colspan='2'>[[4pnp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNP FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnp OCA], [https://pdbe.org/4pnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnp RCSB], [https://www.ebi.ac.uk/pdbsum/4pnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnp ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnp OCA], [http://www.ebi.ac.uk/pdbsum/4pnp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4pnp RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/PNPH_BOVIN PNPH_BOVIN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/4pnp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4pnp ConSurf].
+<div style="clear:both"></div>
-'''THE HIGH RESOLUTION CRYSTAL STRUCTURE OF BOVINE SPLEEN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX FORMS WITH PHOSPHATE AND 9-DEAZAINOSINE'''
+==See Also==
+*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-PNP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNP OCA].
 [[Category: Bos taurus]]
-[[Category: Purine-nucleoside phosphorylase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Ealick SE]]
-[[Category: Ealick, S E.]]
+[[Category: Mao C]]
-[[Category: Mao, C.]]
+[[Category: Pugmire MJ]]
-[[Category: Pugmire, M J.]]
-[[Category: nucleotide metabolism]]
-[[Category: phosphorylase]]
-[[Category: salvage pathway]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:55 2008''