4o30: Difference between revisions
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==Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy== | |||
<StructureSection load='4o30' size='340' side='right'caption='[[4o30]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o30]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O30 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o30 OCA], [https://pdbe.org/4o30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o30 RCSB], [https://www.ebi.ac.uk/pdbsum/4o30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o30 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ATXR5_RICCO ATXR5_RICCO] Histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). Has much higher activity on nucleosomes containing H3.1 than H3.3. Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ricinus communis]] | |||
[[Category: Bergamin E]] | |||
[[Category: Couture JF]] | |||
[[Category: Mongeon V]] | |||
Latest revision as of 15:37, 1 March 2024
Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcyCrystal structure of ATXR5 in complex with histone H3.1 and AdoHcy
Structural highlights
FunctionATXR5_RICCO Histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). Has much higher activity on nucleosomes containing H3.1 than H3.3. Involved in the formation of constitutive heterochromatin and the silencing of heterochromatic elements (By similarity). |
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