4o2r: Difference between revisions
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==Structure of Mus musculus Rheb G63V mutant bound to GDP== | |||
<StructureSection load='4o2r' size='340' side='right'caption='[[4o2r]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O2R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o2r OCA], [https://pdbe.org/4o2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o2r RCSB], [https://www.ebi.ac.uk/pdbsum/4o2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o2r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RHEB_MOUSE RHEB_MOUSE] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity). | |||
==See Also== | |||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Ho J]] | |||
[[Category: Ikura M]] | |||
[[Category: Ishiyama N]] | |||
[[Category: Marshall CB]] | |||
[[Category: Mazhab-Jafari MT]] | |||
[[Category: Stambolic V]] | |||
Latest revision as of 15:37, 1 March 2024
Structure of Mus musculus Rheb G63V mutant bound to GDPStructure of Mus musculus Rheb G63V mutant bound to GDP
Structural highlights
FunctionRHEB_MOUSE Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity). See Also |
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