4n9d: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4n9d is ON HOLD
+==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
+<StructureSection load='4n9d' size='340' side='right'caption='[[4n9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4n9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HJ:4-({[(4-TERT-BUTYLPHENYL)SULFONYL]AMINO}METHYL)-N-(PYRIDIN-3-YL)BENZAMIDE'>2HJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9d OCA], [https://pdbe.org/4n9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9d RCSB], [https://www.ebi.ac.uk/pdbsum/4n9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
+==See Also==
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
-Description: Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Baumeister T]]
+[[Category: Bravo B]]
+[[Category: Dragovich PS]]
+[[Category: Giannetti AM]]
+[[Category: Ho Y]]
+[[Category: Hua R]]
+[[Category: Li G]]
+[[Category: Liang X]]
+[[Category: O'Brien T]]
+[[Category: Oh A]]
+[[Category: Skelton NJ]]
+[[Category: Wang C]]
+[[Category: Wang W]]
+[[Category: Wang Y]]
+[[Category: Xiao Y]]
+[[Category: Yuen P]]
+[[Category: Zak M]]
+[[Category: Zhao G]]
+[[Category: Zhao Q]]
+[[Category: Zheng X]]