4mz6: Difference between revisions

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New page: '''Unreleased structure''' The entry 4mz6 is ON HOLD Authors: Marfori, M, Rona, G, Vertessy, B.G, Kobe, B Description: Structure of importin-alpha: dUTPase S11E NLS mutant complex
 
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'''Unreleased structure'''


The entry 4mz6 is ON HOLD
==Structure of importin-alpha: dUTPase S11E NLS mutant complex==
<StructureSection load='4mz6' size='340' side='right'caption='[[4mz6]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mz6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4fds 4fds]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZ6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz6 OCA], [https://pdbe.org/4mz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mz6 RCSB], [https://www.ebi.ac.uk/pdbsum/4mz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>


Authors: Marfori, M, Rona, G, Vertessy, B.G, Kobe, B
==See Also==
 
*[[DUTPase 3D structures|DUTPase 3D structures]]
Description: Structure of importin-alpha: dUTPase S11E NLS mutant complex
*[[Importin 3D structures|Importin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kobe B]]
[[Category: Marfori M]]
[[Category: Rona G]]
[[Category: Vertessy BG]]

Latest revision as of 15:30, 1 March 2024

Structure of importin-alpha: dUTPase S11E NLS mutant complexStructure of importin-alpha: dUTPase S11E NLS mutant complex

Structural highlights

4mz6 is a 3 chain structure with sequence from Homo sapiens and Mus musculus. This structure supersedes the now removed PDB entry 4fds. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.88Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUT_HUMAN This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[1]

See Also

References

  1. ↑ Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593

4mz6, resolution 1.88Å

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