4mz5: Difference between revisions

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-{{STRUCTURE_4mz5|  PDB=4mz5  |  SCENE=  }}
-===Structure of importin-alpha: dUTPase NLS complex===
-==Function==
+==Structure of importin-alpha: dUTPase NLS complex==
-[[http://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>  [[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
+<StructureSection load='4mz5' size='340' side='right'caption='[[4mz5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mz5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4fdr 4fdr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MZ5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz5 OCA], [https://pdbe.org/4mz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4mz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mz5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>
-==About this Structure==
+==See Also==
-[[4mz5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4fdr 4fdr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ5 OCA].
+*[[DUTPase 3D structures|DUTPase 3D structures]]
+*[[Importin 3D structures|Importin 3D structures]]
-==Reference==
+== References ==
-<references group="xtra"/><references/>
+<references/>
-[[Category: Lk3 transgenic mice]]
+__TOC__
-[[Category: Kobe, B.]]
+</StructureSection>
-[[Category: Marfori, M.]]
+[[Category: Homo sapiens]]
-[[Category: Rona, G.]]
+[[Category: Large Structures]]
-[[Category: Vertessy, B G.]]
+[[Category: Mus musculus]]
-[[Category: Arm repeat]]
+[[Category: Kobe B]]
-[[Category: Importin]]
+[[Category: Marfori M]]
-[[Category: Nucleus]]
+[[Category: Rona G]]
-[[Category: Protein transport]]
+[[Category: Vertessy BG]]