4ltb: Difference between revisions

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-{{STRUCTURE_4ltb|  PDB=4ltb  |  SCENE=  }}
-===Coiled-coil domain of TRIM25===
-{{ABSTRACT_PUBMED_24550273}}
-==About this Structure==
+==Coiled-coil domain of TRIM25==
-[[4ltb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTB OCA].
+<StructureSection load='4ltb' size='340' side='right'caption='[[4ltb]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ltb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LTB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ltb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ltb OCA], [https://pdbe.org/4ltb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ltb RCSB], [https://www.ebi.ac.uk/pdbsum/4ltb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ltb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRI25_HUMAN TRI25_HUMAN] Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.<ref>PMID:16352599</ref> <ref>PMID:17069755</ref> <ref>PMID:17392790</ref>
-==Reference==
+==See Also==
-<ref group="xtra">PMID:024550273</ref><references group="xtra"/><references/>
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
-[[Category: Okreglicka, K.]]
+== References ==
-[[Category: Pornillos, O.]]
+<references/>
-[[Category: Sanchez, J G.]]
+__TOC__
-[[Category: Coiled-coil]]
+</StructureSection>
-[[Category: Metal binding protein]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Okreglicka K]]
+[[Category: Pornillos O]]
+[[Category: Sanchez JG]]