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==Crystal structure of the Cbk1-Mob2 kinase-coactivator complex==
==Crystal structure of the Cbk1-Mob2 kinase-coactivator complex==
<StructureSection load='4lqs' size='340' side='right' caption='[[4lqs]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4lqs' size='340' side='right'caption='[[4lqs]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lqs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LQS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LQS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lqp|4lqp]], [[4lqq|4lqq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lqs OCA], [https://pdbe.org/4lqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lqs RCSB], [https://www.ebi.ac.uk/pdbsum/4lqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lqs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lqs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lqs RCSB], [http://www.ebi.ac.uk/pdbsum/4lqs PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CBK1_YEAST CBK1_YEAST]] Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation. [[http://www.uniprot.org/uniprot/MOB2_YEAST MOB2_YEAST]] Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role in the prevention of nuclear export of ACE2 from the daughter cell nucleus after mitotic exit. It coordinates ACE2-dependent transcription with mitotic exit network activation.<ref>PMID:11747810</ref> <ref>PMID:12196508</ref> 
[https://www.uniprot.org/uniprot/CBK1_YEAST CBK1_YEAST] Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.
== References ==
 
<references/>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Gogl, G]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Remenyi, A]]
[[Category: Gogl G]]
[[Category: Kinase]]
[[Category: Remenyi A]]
[[Category: Transferase-transferase activator complex]]

Latest revision as of 15:21, 1 March 2024

Crystal structure of the Cbk1-Mob2 kinase-coactivator complexCrystal structure of the Cbk1-Mob2 kinase-coactivator complex

Structural highlights

4lqs is a 2 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CBK1_YEAST Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.

See Also

4lqs, resolution 3.30Å

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