4lez: Difference between revisions

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-{{STRUCTURE_4lez|  PDB=4lez  |  SCENE=  }}
-===Structure of mouse cGAS bound to an 18bp DNA and cGAS product===
-{{ABSTRACT_PUBMED_24332030}}
-==Function==
+==Structure of mouse cGAS bound to an 18bp DNA and cGAS product==
-[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
+<StructureSection load='4lez' size='340' side='right'caption='[[4lez]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4lez]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LEZ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lez OCA], [https://pdbe.org/4lez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lez RCSB], [https://www.ebi.ac.uk/pdbsum/4lez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lez ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
-==About this Structure==
+==See Also==
-[[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA].
+*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:024332030</ref><references group="xtra"/><references/>
+[[Category: Large Structures]]
-[[Category: Li, P.]]
+[[Category: Mus musculus]]
-[[Category: Dna sensor]]
+[[Category: Li P]]
-[[Category: Ntase]]
-[[Category: Transferase-dna complex]]