4ldm: Difference between revisions

Latest revision as of 15:19, 1 March 2024

Crystal Structure of an RNA-free VP40 Octameric RingCrystal Structure of an RNA-free VP40 Octameric Ring

Structural highlights

4ldm is a 1 chain structure with sequence from Zaire ebolavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.85Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VP40_EBOZM Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.^[1] ^[2]

References

↑ Irie T, Licata JM, Harty RN. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology. 2005 Jun 5;336(2):291-8. PMID:15892969 doi:10.1016/j.virol.2005.03.027
↑ Johnson RF, Bell P, Harty RN. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology. Virol J. 2006 May 23;3:31. PMID:16719918 doi:10.1186/1743-422X-3-31

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OCA

[1] Irie T, Licata JM, Harty RN. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology. 2005 Jun 5;336(2):291-8. PMID:15892969 doi:10.1016/j.virol.2005.03.027

[2] Johnson RF, Bell P, Harty RN. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology. Virol J. 2006 May 23;3:31. PMID:16719918 doi:10.1186/1743-422X-3-31

[1]

[2]

@@ Line 1: / Line 1: @@
-{{STRUCTURE_4ldm|  PDB=4ldm  |  SCENE=  }}
-===Crystal Structure of an RNA-free VP40 Octameric Ring===
-==Function==
+==Crystal Structure of an RNA-free VP40 Octameric Ring==
-[[http://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM]] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
+<StructureSection load='4ldm' size='340' side='right'caption='[[4ldm]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[4ldm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDM FirstGlance]. <br>
-[[4ldm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDM OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldm OCA], [https://pdbe.org/4ldm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldm RCSB], [https://www.ebi.ac.uk/pdbsum/4ldm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldm ProSAT]</span></td></tr>
-==Reference==
+</table>
-<references group="xtra"/><references/>
+== Function ==
+[https://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Zaire ebolavirus]]
-[[Category: Ableson, D M.]]
+[[Category: Ableson DM]]
-[[Category: Bornholdt, Z A.]]
+[[Category: Bornholdt ZA]]
-[[Category: Saphire, E O.]]
+[[Category: Saphire EO]]
-[[Category: Ebolavirus matrix protein]]
-[[Category: Rna binding ring]]
-[[Category: Viral protein]]
-[[Category: Viral transcription regulation]]

4ldm: Difference between revisions

Latest revision as of 15:19, 1 March 2024

Crystal Structure of an RNA-free VP40 Octameric RingCrystal Structure of an RNA-free VP40 Octameric Ring

Structural highlights

Function

References

Contents

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4ldm: Difference between revisions

Latest revision as of 15:19, 1 March 2024

Crystal Structure of an RNA-free VP40 Octameric RingCrystal Structure of an RNA-free VP40 Octameric Ring

Structural highlights

Function

References

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