4l9u: Difference between revisions

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-'''Unreleased structure'''
-The entry 4l9u is ON HOLD  until Paper Publication
+==Structure of C-terminal coiled coil of RasGRP1==
+<StructureSection load='4l9u' size='340' side='right'caption='[[4l9u]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Iwig, J.S., Vercoulen, Y., Das, R., Barros, T., Limnander, A., Che, Y., Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4l9u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9U FirstGlance]. <br>
-Description: Structure of C-terminal coiled coil of RasGRP1
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6014&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9u OCA], [https://pdbe.org/4l9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9u RCSB], [https://www.ebi.ac.uk/pdbsum/4l9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9u ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
+== Function ==
+[https://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Barros T]]
+[[Category: Che Y]]
+[[Category: Das R]]
+[[Category: Iwig JS]]
+[[Category: Kuriyan J]]
+[[Category: Limnander A]]
+[[Category: Pelton JG]]
+[[Category: Roose JP]]
+[[Category: Vercoulen Y]]
+[[Category: Wemmer DE]]