4jt3: Difference between revisions

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New page: '''Unreleased structure''' The entry 4jt3 is ON HOLD Authors: Qiu, W., Harris-Brandts, M., Feher, M., Awrey, D. E., Chirgadze, N. Y. Description: Crystal Structure of TTK kinase domain...
 
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'''Unreleased structure'''


The entry 4jt3 is ON HOLD
==Crystal Structure of TTK kinase domain with an inhibitor: 400740==
<StructureSection load='4jt3' size='340' side='right'caption='[[4jt3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JT3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PH:2-PHENYL-N-[3-(3-SULFAMOYLPHENYL)-2H-INDAZOL-5-YL]ACETAMIDE'>1PH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jt3 OCA], [https://pdbe.org/4jt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jt3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jt3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>


Authors: Qiu, W., Harris-Brandts, M., Feher, M., Awrey, D. E., Chirgadze, N. Y.
==See Also==
 
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
Description: Crystal Structure of TTK kinase domain with an inhibitor: 400740
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Awrey DE]]
[[Category: Chirgadze NY]]
[[Category: Feher M]]
[[Category: Harris-Brandts M]]
[[Category: Qiu W]]

Latest revision as of 15:06, 1 March 2024

Crystal Structure of TTK kinase domain with an inhibitor: 400740Crystal Structure of TTK kinase domain with an inhibitor: 400740

Structural highlights

4jt3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TTK_HUMAN Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

See Also

References

  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

4jt3, resolution 2.20Å

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