4jr5: Difference between revisions

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-{{STRUCTURE_4jr5|  PDB=4jr5  |  SCENE=  }}
-===Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
-{{ABSTRACT_PUBMED_23617784}}
-==Function==
+==Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors==
-[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+<StructureSection load='4jr5' size='340' side='right'caption='[[4jr5]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4jr5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JR5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.906&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LS:1-[4-(PIPERIDIN-1-YLSULFONYL)PHENYL]-3-(PYRIDIN-3-YLMETHYL)THIOUREA'>1LS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jr5 OCA], [https://pdbe.org/4jr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jr5 RCSB], [https://www.ebi.ac.uk/pdbsum/4jr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jr5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-==About this Structure==
+==See Also==
-[[4jr5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR5 OCA].
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:023617784</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
-[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Large Structures]]
-[[Category: Bair, K W.]]
+[[Category: Bair KW]]
-[[Category: Bauer, P.]]
+[[Category: Bauer P]]
-[[Category: Baumeister, T.]]
+[[Category: Baumeister T]]
-[[Category: Buckmelter, A J.]]
+[[Category: Buckmelter AJ]]
-[[Category: Caligiuri, M.]]
+[[Category: Caligiuri M]]
-[[Category: Clodfelter, K H.]]
+[[Category: Clodfelter KH]]
-[[Category: Dragovich, P S.]]
+[[Category: Dragovich PS]]
-[[Category: Gunzner-Toste, J.]]
+[[Category: Gunzner-Toste J]]
-[[Category: Han, B.]]
+[[Category: Han B]]
-[[Category: Ho, Y.]]
+[[Category: Ho Y]]
-[[Category: Kley, N.]]
+[[Category: Kley N]]
-[[Category: Lin, J.]]
+[[Category: Lin J]]
-[[Category: Oh, A.]]
+[[Category: Oh A]]
-[[Category: Reynolds, D J.]]
+[[Category: Reynolds DJ]]
-[[Category: Sharma, G.]]
+[[Category: Sharma G]]
-[[Category: Smith, C C.]]
+[[Category: Smith CC]]
-[[Category: Wang, W.]]
+[[Category: Wang W]]
-[[Category: Wang, Z.]]
+[[Category: Wang Z]]
-[[Category: Yuen, P.]]
+[[Category: Yuen P]]
-[[Category: Zak, M.]]
+[[Category: Zak M]]
-[[Category: Zhao, G.]]
+[[Category: Zhao G]]
-[[Category: Zheng, X.]]
+[[Category: Zheng X]]
-[[Category: Transferase-transferase inhibitor complex]]