4jnm: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 4jnm is ON HOLD
+==Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties==
+<StructureSection load='4jnm' size='340' side='right'caption='[[4jnm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4jnm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LJ:1-[(6-AMINOPYRIDIN-3-YL)METHYL]-3-[4-(PHENYLSULFONYL)PHENYL]UREA'>1LJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnm OCA], [https://pdbe.org/4jnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jnm RCSB], [https://www.ebi.ac.uk/pdbsum/4jnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jnm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y., Kley, N., Liederer, B., Lin, J., Mukadam, S., O'Brien, T., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Oh, A., Wang, W., Wang, Z., Xiao, Y., Yuen, P., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
+==See Also==
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
-Description: Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bair KW]]
+[[Category: Bauer P]]
+[[Category: Baumeister T]]
+[[Category: Buckmelter AJ]]
+[[Category: Caligiuri M]]
+[[Category: Clodfelter KH]]
+[[Category: Dragovich PS]]
+[[Category: Fu B]]
+[[Category: Gunzner-Toste J]]
+[[Category: Han B]]
+[[Category: Ho Y]]
+[[Category: Kley N]]
+[[Category: Liederer B]]
+[[Category: Lin J]]
+[[Category: Mukadam S]]
+[[Category: O'Brien T]]
+[[Category: Oh A]]
+[[Category: Reynolds DJ]]
+[[Category: Sharma G]]
+[[Category: Skelton N]]
+[[Category: Smith CC]]
+[[Category: Wang W]]
+[[Category: Wang Z]]
+[[Category: Xiao Y]]
+[[Category: Yuen P]]
+[[Category: Zak M]]
+[[Category: Zhang L]]
+[[Category: Zhao G]]
+[[Category: Zheng X]]