4jne: Difference between revisions
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New page: '''Unreleased structure''' The entry 4jne is ON HOLD Authors: Qi, R., Sarbeng, E.B., Liu, Q., Le, K.Q., Xu, X., Xu, H., Yang, J., Wong, J.L., Vorvis, C., Hendrickson, W.A., Zhou, L., Li... |
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==Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP== | |||
<StructureSection load='4jne' size='340' side='right'caption='[[4jne]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4jne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jne OCA], [https://pdbe.org/4jne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jne RCSB], [https://www.ebi.ac.uk/pdbsum/4jne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jne ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] | |||
==See Also== | |||
*[[Heat Shock Protein structures|Heat Shock Protein structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Hendrickson WA]] | |||
[[Category: Le KQ]] | |||
[[Category: Liu Q]] | |||
[[Category: Qi R]] | |||
[[Category: Sarbeng EB]] | |||
[[Category: Vorvis C]] | |||
[[Category: Wong JL]] | |||
[[Category: Xu H]] | |||
[[Category: Xu X]] | |||
[[Category: Yang J]] | |||
[[Category: Zhou L]] | |||
Latest revision as of 15:05, 1 March 2024
Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATPAllosteric opening of the polypeptide-binding site when an Hsp70 binds ATP
Structural highlights
FunctionDNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] See Also |
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